The Henry reaction is an organic reaction used to convert a nitroalkane with an α-hydrogen and an aldehyde or ketone to a β-nitro alcohol using a base catalyst. Reaction Map: The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. Examples. The alkoxide then picks up a proton from the conjugate acid of the base (H2O in this case) to give the final β-nitro alcohol product and regenerate the base catalyst. The Henry Reaction is a base-catalyzed C-C bond-forming reaction between nitroalkanes and aldehydes or ketones.
The aza-Henry reaction is also used to produce nitroamines and can be a reliable synthetic route for the synthesis of vicinal diamines. when R = H), the products tend to eliminate water to give nitroalkenes. It is similar to the Aldol Addition, and also referred to as the Nitro Aldol Reaction. One reaction in which ammonium acetate is commonly used in is Henry reactions. Nitroalkenes are often the desired product of a Henry reaction. Ammonium acetate is labeled as an irritant. A mixture of the SM (150 g, 0.999 mol) and NH4OAc (30.8 g, 0.40 mol) in nitromethane (1.5 L) was refluxed for 16 h. The mixture was concentrated then . Of these some of the most important include employing high-pressure and sometimes solvent free conditions to improve chemo- and regioselectivity and chiral metal catalysts to induce enantio-or diastereoselectivity. The mechanism begins with deprotonation of the nitroalkane by the base to give a resonance stabilize anionic intermediate which subsequently attacks the carbonyl compound to form an alkoxide. . This usually is achieved by using elevated reaction temperatures.
It can be useful for applications that require buffered solutions.
One reaction in which ammonium acetate is commonly used in is Henry reactions. . The Henry reaction is an organic reaction used to convert a nitroalkane with an α-hydrogen and an aldehyde or ketone to a β-nitro alcohol using a base catalyst. Henry Reaction. 1) Patent Reference: WO2016014463, page 94, (6.7 MB), 3) www.sigmaaldrich.com: Ammonium acetate (link), 4) www.alfa.com: A16343 Ammonium acetate, 97% (link). If acidic protons are available (i.e. . Ammonium acetate (NH4OAc) is a salt formed from the reaction of ammonia and acetic acid. There have been a series of modifications made to the Henry reaction.
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