As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies. I took myself off the stuff today there is no way I will take any more. Blood vessels become less constricted and somehow the brain interprets this as less anxiety. The supported beta blockers are: Metoprolol succinate, Bisoprolol, and Carvedilol. I gained 8 lbs in 4 weeks from fluid retention, I'm tired all the time when I took it, and I have wheezes from being short of breath! I like to know what I’m ingesting, can you explain what myocardial oxygen consumption is? And so the issue is that this will decrease stroke volume, thus decreasing cardiac output, thus exacerbating heart failure (since heart failure is the inability of the heart to create enough output, and backs up into the pulmonary and venous circulation). I read a previous comment about becoming depressed after starting on this drug. 2. Edit: got it mostly right, but the BBs with benefit are only specific ones, based on receptor selectivity. I have read various studies for and against the usage of beta blockers, but it appears after initialization, the myocardial depression that accompanies the onset could also be life threatening. There are ample antihypertensives to choose from. It definitely helped me!❤️One time, accidentally overlapping the time frames that I normally take it I experienced an adverse effect taking it 2 hours earlier one day(by accident)than the usual time and my pulse decreased to 45 BPM and my BP actually increased! Thinking maybe low dose Lisinopril for my eye. In that time my blood pressure went up but not down. I switched to some free samples of Bystolic 5mg and I’ve only been on it for 4 days, but so far I hope it works. This is actually a very commonly discussed topic on rounds for me. 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